{"id":93817,"date":"2025-04-24T04:50:47","date_gmt":"2025-04-24T04:50:47","guid":{"rendered":"https:\/\/neclink.com\/index.php\/2025\/04\/24\/what-science-says-about-food-additives\/"},"modified":"2025-04-24T04:50:47","modified_gmt":"2025-04-24T04:50:47","slug":"what-science-says-about-food-additives","status":"publish","type":"post","link":"https:\/\/neclink.com\/index.php\/2025\/04\/24\/what-science-says-about-food-additives\/","title":{"rendered":"What Science Says About Food Additives"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<p>Yves here. This post usefully goes a bit deeper into the regulatory system for food additives. It should come as no surprise that in the US, it remarkably permissive.<\/p>\n<p>The article alludes to but does not address the idea that some foods, particularly snack foods, are engineered to seem very rewarding, such as the mouth feel of a Cheeto. So there\u2019s an additional layer of issues: not only can additives be directly harmful to health, but they can be indirectly damaging by being incorporated to encourage excessive consumption, which then produces overweight and obesity.<\/p>\n<p><em><strong>By Charles Schmidt, a senior contributor to Undark and has also written for Science, Nature Biotechnology, Scientific American, Discover Magazine, and The Washington Post, among other publications. Originally published at <a href=\"https:\/\/undark.org\/2025\/04\/21\/rfk-science-food-additives\/\" target=\"_blank\" rel=\"nofollow noopener\">Undark<\/a><\/strong><\/em><\/p>\n<p>In a video posted to <a href=\"https:\/\/www.youtube.com\/watch?v=0_OjKe4BuDE\" target=\"_blank\" rel=\"nofollow noopener\">YouTube<\/a> in September, Robert F. Kennedy Jr. took aim at U.S. health agencies that he said have allowed for the mass poisoning of American children. Standing behind packages of Cheez-Its, Doritos, and Cap\u2019n Crunch cereal displayed on a kitchen counter, the future head of the Department of Health and Human Services warned that chronic disease rates in the United States have soared. \u201cHow in the world did this happen?\u201d Kennedy asked. Many of our chronic ailments, he asserted, can be blamed on chemical additives in processed foods. \u201cIf we took all these chemicals out,\u201d he said, \u201cour nation would get healthier immediately.\u201d<\/p>\n<p>During his Senate confirmation hearings in January, Kennedy singled out a Food and Drug Administration standard by which companies can introduce new additives to foods without notifying regulators or the public. The standard, called \u201cgenerally recognized as safe,\u201d or <a href=\"https:\/\/www.fda.gov\/animal-veterinary\/animal-food-feeds\/generally-recognized-safe-gras-notification-program\" target=\"_blank\" rel=\"nofollow noopener\">GRAS<\/a>, was adopted in 1958 and geared initially towards benign substances such as vinegar and baking powder. However, most of the chemical additives introduced in recent decades passed through the so-called GRAS loophole: The FDA requires manufacturers to affirm GRAS additives are safe, but the companies don\u2019t have to release the data, and they are in effect self-regulating. In 2013, the Pew Charitable Trusts estimated that more than 10,000 additives were in processed foods and that 3,000 of them had never been reviewed by the FDA. Out of that group, Pew estimated that 1,000 were self-affirmed as GRAS by additive manufacturers.<\/p>\n<p>The GRAS system came into effect \u201cwell before the majority of calories consumed by adults and children were in the form of ultra-processed food products,\u201d Jennifer Pomeranz, a public health attorney and associate professor at New York University\u2019s School of Global Public Health, wrote in an email to Undark. By self-affirming that a given additive is GRAS, companies can avoid time-consuming regulatory submissions. The process is easier and cheaper for companies, Pomeranz wrote, but it undermines \u201cpublic trust of the food supply.\u201d<\/p>\n<p>On March 10, Kennedy <a href=\"https:\/\/www.hhs.gov\/about\/news\/2025\/03\/10\/hhs-secretary-kennedy-directs-fda-explore-rulemaking-eliminate-pathway-companies-self-affirm-food-ingredients-safe.html\" target=\"_blank\" rel=\"nofollow noopener\">directed<\/a> the FDA to explore rule-making strategies for eliminating the self-affirmed GRAS pathway for food ingredients, claiming the move would provide transparency for consumers. At a March meeting with food industry executives, he also cited the elimination of <a href=\"https:\/\/www.nytimes.com\/2025\/03\/11\/health\/rfk-jr-food-safety-artificial-dyes.html\" target=\"_blank\" rel=\"nofollow noopener\">artificial dyes<\/a> \u2014 which go through a different FDA approval process \u2014 from foods as a top priority.<\/p>\n<p><iframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube-nocookie.com\/embed\/0_OjKe4BuDE?si=iSrGAVcnHQYIDaxN\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen=\"\"><\/iframe><figcaption class=\"wp-element-caption\">In a video posted in September, Robert F. Kennedy Jr. took aim at U.S. health agencies. Many of our chronic ailments, he asserted, can be blamed on chemical additives in processed foods. \u201cIf we took all these chemicals out,\u201d he said, \u201cour nation would get healthier immediately.\u201d<em>Visual: Robert F. Kennedy Jr.\/YouTube<\/em><\/figcaption><\/p>\n<p>Kennedy\u2019s goal to rid the food supply of chemical additives is winning accolades from nutrition experts, but it also raises challenging questions. The FDA would need more money and staff to expand oversight of food chemicals, which flies in the face of President Donald Trump\u2019s promise to cut \u2014 not increase \u2014 federal spending.<\/p>\n<p>Meanwhile, questions remain about how much of a role food additives actually play in chronic disease and whether tightening the GRAS loophole would really help. Food additives are a \u201cpiece of the puzzle,\u201d said Kathleen Melanson, a nutrition scientist and professor at the University of Rhode Island. But, she added in an email, \u201cother aspects of food and diets should not be ignored.\u201d Still, the focus on food additives strikes a chord with those who say changes to FDA policy are long overdue. \u201cThere\u2019s an opportunity to get things done,\u201d said Emily M. Broad Leib, a clinical professor at Harvard Law School. \u201cIt\u2019s generated such a response that\u2019s been, I think, echoed across the political spectrum.\u201d<\/p>\n<hr\/>\n<p>Chemical food additives fall into a few general categories, including dyes, sweeteners, and emulsifiers that improve food texture and shelf life. These chemicals began appearing in foods well over a <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S104345261830007X\" target=\"_blank\" rel=\"nofollow noopener\">century<\/a> ago, and over time, they helped to fuel the rise of <a href=\"https:\/\/undark.org\/2020\/06\/26\/book-review-ingredients\/\" target=\"_blank\" rel=\"nofollow noopener\">highly processed foods<\/a>. Children and adolescents are now among the biggest consumers.<\/p>\n<p>A U.S.-based <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2782866\" target=\"_blank\" rel=\"nofollow noopener\">study<\/a> showed that in 2018, people aged 2 to 19 got 67 percent of their calories from ultra-processed foods as defined by Carlos Monteiro, an epidemiologist and emeritus professor at the University of S\u00e3o Paulo\u2019s School of Public Health, and his co-authors. The team\u2019s widely cited classification scheme \u2014 named Nova \u2014 divides food into four categories. The first category includes natural or minimally processed foods, whereas ultra-processed foods at the opposite end of the spectrum comprise \u201cformulations of often chemically manipulated cheap ingredients, such as modified starches, sugars, oils, fats, and protein isolates, with little if any whole food added. These foods are made palatable and attractive by using combinations of flavours, colours, emulsifiers, thickeners, and other additives,\u201d Monteiro and two University of S\u00e3o Paulo colleagues wrote in a 2024 <a href=\"https:\/\/www.bmj.com\/content\/384\/bmj.q439\" target=\"_blank\" rel=\"nofollow noopener\">editorial<\/a>. Examples include soft drinks, chicken nuggets, frozen meals, packaged snacks, and ready-to-eat cereals.<\/p>\n<p>Designed for what Melanson described as \u201chedonic appeal,\u201d ultra-processed foods stimulate reward centers in the brain; some scientists have <a href=\"https:\/\/www.nutritional-psychology.org\/scientists-propose-that-ultra-processed-foods-be-classified-as-addictive-substances\/\" target=\"_blank\" rel=\"nofollow noopener\">even suggested<\/a> that such foods are addictive. Research has associated ultra-processed foods with <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00394-020-02367-1\" target=\"_blank\" rel=\"nofollow noopener\">obesity<\/a>, <a href=\"https:\/\/www.clinicalnutritionjournal.com\/article\/S0261-5614(20)30693-2\/abstract\" target=\"_blank\" rel=\"nofollow noopener\">type 2 diabetes<\/a>, <a href=\"https:\/\/www.clinicalnutritionjournal.com\/article\/S0261-5614(23)00099-7\/abstract\" target=\"_blank\" rel=\"nofollow noopener\">cancer<\/a>, and <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2809727\" target=\"_blank\" rel=\"nofollow noopener\">depression<\/a>. Kennedy\u2019s attacks center less on the foods\u2019 nutritional deficiencies than on the supposed toxicity of their synthetic ingredients.<\/p>\n<p>Other regulators increasingly share his concerns. In March, West Virginia took the unprecedented step of banning seven food dyes: Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 5, Yellow No. 6, Red No. 40, and Red No. 3. The ban goes into effect in 2028, and at least 20 other states are considering similar measures, according to <a href=\"https:\/\/www.nytimes.com\/2025\/03\/24\/well\/west-virginia-food-dye-ban.html\" target=\"_blank\" rel=\"nofollow noopener\">The New York Times<\/a>. In 2023, California banned <a href=\"https:\/\/www.npr.org\/2023\/10\/10\/1204839281\/california-ban-food-additives-red-dye-3-propylparaben-candy\" target=\"_blank\" rel=\"nofollow noopener\">four<\/a> synthetic food substances: potassium bromate, a conditioner that helps flour rise during baking; brominated vegetable oil, or BVO, a stabilizer for artificial flavors; propylparaben, an antimicrobial preservative; and Red Dye No. 3, a colorant historically derived from coal tars that is used in soft drinks, candy, and drugs.<\/p>\n<p>The FDA followed suit with its own <a href=\"https:\/\/www.fda.gov\/food\/hfp-constituent-updates\/fda-revoke-authorization-use-red-no-3-food-and-ingested-drugs\" target=\"_blank\" rel=\"nofollow noopener\">ban<\/a> on Red Dye No. 3 in January of this year, citing evidence that the chemical causes cancer in rats. (The FDA noted the way the dye causes cancer in rats does not happen in humans.) Used in food, drugs, and cosmetics for over a century, Red Dye No. 3 was <a href=\"https:\/\/academic.oup.com\/mutage\/article-abstract\/1\/4\/253\/1343848\" target=\"_blank\" rel=\"nofollow noopener\">first shown<\/a> to be carcinogenic in rodents during a study conducted in 1977. After being exposed to the dye in utero, rats were fed a daily dose (measured by animal weight) that was more than 24,000 times as high as what the World Health Organization currently deems acceptable for human consumption. In all, 16 out of 69 male rats (but none of the females) developed thyroid tumors after a lifetime of exposure, though fewer rats developed tumors at lower doses. The FDA saw fit to ban Red Dye No. 3 from cosmetics in 1990, while allowing the dye to remain in food for over 30 years.<\/p>\n<p>The recent ban has drawn mixed reactions. Roger Clemens, an adjunct professor of pharmacology and pharmaceutical sciences at the University of Southern California and past president of the Institute of Food Technologists, an industry trade group, said that Red Dye No. 3 has never been shown to cause cancer in humans. But Maricel Maffini, a biochemist and independent consultant, said the FDA is bound to a legal provision called the <a href=\"https:\/\/www.gao.gov\/products\/hrd-82-3\" target=\"_blank\" rel=\"nofollow noopener\">Delaney Clause<\/a>, which prohibits any food additive with evidence of carcinogenic effects in animals or humans, regardless of the dose. The provision assumes \u201cthat even a single molecule of a carcinogen could cause cancer,\u201d Maffini said, so when it comes to allowing such compounds in food, the answer is \u201cno \u2014 period.\u201d The FDA and HHS did not provide answers to emailed questions submitted by Undark during the preparation of this story.<\/p>\n<p><img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-291018\" src=\"https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive.jpg\" alt=\"\" width=\"600\" height=\"392\" srcset=\"https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive.jpg 2500w, https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive-300x196.jpg 300w, https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive-1024x669.jpg 1024w, https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive-768x502.jpg 768w, https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive-1536x1004.jpg 1536w, https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive-2048x1339.jpg 2048w, https:\/\/www.nakedcapitalism.com\/wp-content\/uploads\/2025\/04\/00-food-additive-624x408.jpg 624w\" sizes=\"(max-width: 600px) 100vw, 600px\"\/><\/p>\n<p>The Nova classification scheme, defined by Carlos Monteiro and his co-authors in 2018, divides food into four categories. The first category, at the bottom of this pyramid, includes naturally or minimally processed foods, whereas ultra-processed foods (UPFs) at the top of the pyramid contain \u201cformulations of often chemically manipulated cheap ingredients,\u201d such as modified starches, sugars, oils, fats, and protein isolates,\u201d Monteiro wrote. <em>Visual: <a href=\"https:\/\/www.mdpi.com\/2218-273X\/15\/2\/307#\" target=\"_blank\" rel=\"noopener nofollow\">Vallianou et al, Biomolecules 2025<\/a><\/em><\/p>\n<p>Even before the state and federal bans took effect, food companies were phasing Red Dye No. 3 out voluntarily. The Hershey Company, for instance, told CBS News that it <a href=\"https:\/\/www.cbsnews.com\/news\/red-3-fda-ban-food-drug-brands\/\" target=\"_blank\" rel=\"nofollow noopener\">stopped<\/a> using the dye in 2021. Kantha Shelke, a senior lecturer at Johns Hopkins University and founder of a food science and research firm, said companies often apply a \u201cstealth approach\u201d when pulling controversial ingredients off the market. A quiet transition, she wrote in an email, helps to ensure that existing inventory won\u2019t be \u201crejected by consumers while the reformulated products gradually appeared on store shelves.\u201d<\/p>\n<p>Companies have been quietly phasing out other food dyes as well, including Yellow Dye No. 5, which Kennedy singled out in his YouTube video for allegedly causing \u201ctumors, asthma, developmental delays, neurological damage, ADD, ADHD, hormone disruption, gene damage, anxiety, depression, intestinal injuries.\u201d Also called tartrazine, and also historically derived from coal tars, the dye first appeared in foods during the <a href=\"https:\/\/www.fda.gov\/industry\/color-additives\/color-additives-history\" target=\"_blank\" rel=\"nofollow noopener\">early 20th century<\/a>. By the 1970s, mounting evidence had linked the dye with health problems such as <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2239641\/\" target=\"_blank\" rel=\"nofollow noopener\">urticaria<\/a>, also known as hives. Companies started phasing out tartrazine more than a decade ago, according to Shelke, who is also a member of the Institute of Food Technologists,\u00a0in some cases replacing it with natural alternatives such as paprika and turmeric. However, the bright yellow dye is still found in many conventional items, Shelke wrote in an email, \u201cincluding sodas, candies, cereals, Jell-O, and snack foods.\u201d A recent <a href=\"https:\/\/www.wsj.com\/business\/artificial-food-dyes-database-fcf34296\" target=\"_blank\" rel=\"nofollow noopener\">analysis<\/a> by The Wall Street Journal found that more than one in 10 products in a federal database of 450,000 foods and beverages contained at least one artificial dye. Among these products, 40 percent used three dyes or more.<\/p>\n<p>While cancer fears propelled the demise of Red Dye No. 3, health worries over tartrazine and other dyes center mostly on neurologically driven behavioral problems in children. In a book <a href=\"https:\/\/www.amazon.com\/Why-Your-Child-Hyper-Active-Feingold\/dp\/B004AXUYGI\" target=\"_blank\" rel=\"nofollow noopener\">published<\/a> in 1975, San Francisco-based pediatric allergist Benjamin Feingold blamed behavioral symptoms on intake of synthetic food additives and dyes by the typical American child. He became a minor celebrity championing the \u201cFeingold diet,\u201d which was free of these substances.<\/p>\n<p>Yet as a remedy for the prevention and treatment of attention-deficit\/hyperactivity disorder, or ADHD, the Feingold diet met with controversy, especially among skeptical physicians who felt the supporting evidence was inadequate. Years of ensuing research into dietary interventions for ADHD generated conflicting results. In 2010, the European Union adopted a precautionary stance by <a href=\"https:\/\/www.newhope.com\/regulatory\/eu-requires-food-dye-labeling\" target=\"_blank\" rel=\"nofollow noopener\">requiring<\/a> that foods with synthetic food dyes be labeled to warn of possible adverse effects on activity and attention in children. But despite the urging of groups such as the <a href=\"https:\/\/publications.aap.org\/pediatrics\/article\/142\/2\/e20181408\/37584\/Food-Additives-and-Child-Health\" target=\"_blank\" rel=\"nofollow noopener\">American Academy of Pediatrics<\/a> and the <a href=\"https:\/\/www.cspinet.org\/cspi-news\/synthetic-food-dyes-rainbow-risks\" target=\"_blank\" rel=\"nofollow noopener\">Center for Science in the Public Interest<\/a>, the FDA has yet to require similar labels.<\/p>\n<p>One <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22176942\/\" target=\"_blank\" rel=\"nofollow noopener\">paper<\/a> suggesting that dyes and behavioral effects might be related, which has been cited dozens of times, was co-authored in 2012 by Joel Nigg, a professor of psychiatry at Oregon Health &amp; Science University. Nigg and his team compiled dozens of research studies investigating the role of dietary additives on ADHD symptoms in children. Based on the results of this meta-analysis, Nigg and his colleagues concluded that roughly one third of children with ADHD might respond to a restriction diet free of synthetic additives, and that 8 percent of those children may be sensitive to food dyes specifically. The evidence was too weak to justify policy action \u201cabsent a strong precautionary stance,\u201d they wrote, but also \u201ctoo substantial to dismiss.\u201d<\/p>\n<p>A later 2022 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35484553\/\" target=\"_blank\" rel=\"nofollow noopener\">review<\/a> led by scientists at the California Office of Environmental Health Hazard Assessment reached more definitive conclusions. The OEHHA team compiled 27 clinical trials of children exposed to synthetic food dyes. Most of the trials had dosed children directly with dyes or a placebo on alternating schedules. Parents, teachers, and, in some cases, trained specialists assessed the children\u2019s behavior and in some studies were unaware of when the dye exposures were occurring. Mark Miller, a pediatrician who led the OEHHA review, said doses tested during many of the trials mimicked real life exposure to synthetic food dyes. The dyes had no effect on some children, while others had measurable impacts on attention, impulsivity, learning, memory, and hyperactivity, he said. The combined evidence favoring a link between synthetic dyes and neurobehavioral effects \u201cis very strong,\u201d said Miller, who is now an associate professor at the University of California, San Francisco. The FDA\u2019s exposure limits for these chemicals, called acceptable daily intakes, \u201cmay not be adequate to protect children,\u201d he said.<\/p>\n<p>Clemens is sharply critical of such meta-analyses, claiming they \u201caren\u2019t worth the paper they\u2019re printed on.\u201d Rather than \u201clooking at the totality of the evidence\u201d \u2014 for example, all the published studies pertaining to a given research question \u2014 meta-analyses are restricted to a select subset of individual studies meeting the review authors\u2019 pre-defined inclusion criteria, he said. Clemens recognizes that some people are sensitive to food coloring but also questioned whether scientists know the mechanism by which dyes might exert behavioral effects.<\/p>\n<p>Still, possible mechanisms have been proposed. John Warner, a pediatrician and emeritus professor at Imperial College London, and other researchers published <a href=\"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.2010.09101529\" target=\"_blank\" rel=\"nofollow noopener\">evidence<\/a> suggesting that food dyes might lead to hyperactivity by stimulating the release of histamine, which then binds to receptors in the brain. Histamine is familiar for its roles in allergies and asthma, but the neurotransmitter\u2019s receptors \u201chave been associated with changes in behavior,\u201d Warner said. Warner co-authored a <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(07)61306-3\/abstract\" target=\"_blank\" rel=\"nofollow noopener\">study<\/a> during which children 3, 8, or 9 years old were given fruit drinks supplemented with either food dyes or a placebo. The dyes boosted hyperactivity among some children. Results from an <a href=\"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.2010.09101529\" target=\"_blank\" rel=\"nofollow noopener\">additional study<\/a>, published in 2010, showed that the most affected children had genetic variants \u2014 not specifically associated with ADHD \u2014 that make it difficult for them to break down histamine. These results suggest that food dyes trigger histamine releases that, in turn, might overstimulate those receptors in genetically prone children, resulting in impulsive and hyperactive behavior, Warner explained.<\/p>\n<hr\/>\n<p>An ongoing <a href=\"https:\/\/www.nature.com\/articles\/s41598-021-98496-6\" target=\"_blank\" rel=\"nofollow noopener\">study<\/a> based in Europe might generate further insights into the health effects of food additives. Launched by French researchers in 2009, the NutriNet<em>\u2013<\/em>Sant\u00e9 study is among the world\u2019s largest investigations of nutrition and health, with more than 100,000 participants. The enrolled subjects use barcode readers to scan the food items they consume. \u201cWe can extract information from the packaging related to which additives they were exposed to,\u201d said Bernard Srour, an epidemiologist at the Universit\u00e9 Sorbonne Paris Nord and a co-investigator of the study. The NutriNet<em>\u2013<\/em>Sant\u00e9 team measured levels of most of the approximately 400 additives approved in Europe for packaged food items, allowing them to quantify exposures precisely. Srour declined to comment on an ongoing investigation of synthetic dyes. But he singled out findings on emulsifiers and artificial sweeteners, describing them both as being \u201cassociated with an increased risk of human disease.\u201d<\/p>\n<p>Emulsifiers turn hydrophobic (water-hating) and hydrophilic (water-loving) substances into stable mixtures. Mayonnaise, for instance, relies on a natural emulsifier called lecithin in egg yolks to hold the condiment together so that it doesn\u2019t separate into its watery and oily components. Other natural emulsifiers include carrageenan (made from seaweed), locust bean gum (from carob seeds), mono- and diglycerides (from fatty acids and glycerol), guar gum (from guar beans), and xanthan gum, which is produced by fermenting a bacterium called <em>Xanthomonas campestris<\/em>.<\/p>\n<p>Some evidence suggests that some <a href=\"https:\/\/www.gastrojournal.org\/article\/S0016-5085(21)03728-8\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">emulsifiers<\/a> <a href=\"https:\/\/www.nature.com\/articles\/nature14232\" target=\"_blank\" rel=\"nofollow noopener\">damage<\/a> protective layers of mucus on intestinal surfaces, potentially allowing bacterial toxins, including lipopolysaccharides, to leak into the bloodstream. When lipopolysaccharides bind to receptors on immune cells, they can trigger inflammatory reactions that boost \u201cthe risk of cardiovascular disease and diabetes,\u201d said Katherine Maki, a clinical investigator at the National Institutes of Health. Research by the NutriNet<em>\u2013<\/em>Sant\u00e9 researchers provides supporting evidence. In 2024, the team <a href=\"https:\/\/www.thelancet.com\/journals\/landia\/article\/PIIS2213-8587(24)00086-X\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">reported<\/a> that dietary exposures to carrageenans, guar gum, and xanthan gum elevated the risk of type 2 diabetes for adults in the study.<\/p>\n<p>In Shelke\u2019s view, synthetic emulsifiers may pose comparatively greater health risks. Effective in small amounts and cheaper to use than their natural alternatives, synthetic emulsifiers do not exist in nature, and our microbiome does not have any way to process them, Shelke wrote in an email. Andrew Gewirtz, an immunologist and researcher at Georgia State University, pointed out that unlike natural emulsifiers such as lecithin, which can be broken down by microbes in the small intestine, synthetic emulsifiers pass unrecognized through the gastrointestinal tract and can spend 7 to 8 hours in the colon, interacting with bacteria. In animal models, emulsifiers have been shown to change bacterial gene expression, he said, causing microbes to \u201cexpress virulence factors that make them more aggressive.\u201d<\/p>\n<p>Scientists believe this may also happen in people. Gewirtz advises consumers to avoid carboxymethylcellulose and polysorbate-80 but also suggests people minimize consumption of guar and xanthan gums. Among natural emulsifiers, these \u201chave the biggest impact in mice,\u201d he said, adding \u201cwe don\u2019t know why or how well that translates to humans.\u201d<\/p>\n<p>Shelke, meanwhile, cited an oft-repeated phrase in toxicology, which is that the dose makes the poison. For instance, humans have been consuming xanthan gum in its natural form for millennia, she noted in an email, but not in the concentrated doses now used in food products. Similarly, synthetic emulsifiers consumed in trace amounts can perform their function without harming the microbiome, \u201cwhereas excessive exposure may have adverse effects,\u201d she wrote.<\/p>\n<p>And what of the familiar artificial sweeteners found in packets on restaurant tables and on the ingredient lists of products marketed as low calorie? Many varieties have been introduced over the years, but health evidence on these compounds lacks consensus. For instance, citing high-dose animal studies and limited evidence of an association with liver cancer in humans, the WHO\u2019s International Agency for Research on Cancer classified aspartame as a possible human carcinogen, while the FDA maintains that aspartame is safe when consumed \u201cunder the approved conditions of use.\u201d Cancer worries aside, sweeteners may also alter gut microbiomes in ways that disrupt the body\u2019s control of blood sugar, potentially leading to \u201ctype 2 diabetes as well as weight gain and obesity,\u201d Jotham Suez, an assistant professor for molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health, wrote in an email.<\/p>\n<p>Evidence from the NutriNet<em>\u2013<\/em>Sant\u00e9 cohort and other studies also point to metabolic downsides from artificial sweeteners. Substances that taste sweet trigger the brain to release insulin, a hormone that keeps blood sugar under control. Hundreds of times sweeter than table sugar, products such as aspartame and sucralose (Splenda) can trigger the brain to over-react and release more insulin than necessary. And that excess insulin, Shelke said, \u201ccan then wreak havoc on the other parts of my body.\u201d But if people consume artificial sweeteners and other additives in small amounts once in a while, \u201cthat\u2019s OK,\u201d she added.<\/p>\n<p>In yet another <a href=\"https:\/\/x.com\/SecKennedy\/status\/1900299846025720019\" target=\"_blank\" rel=\"nofollow noopener\">video<\/a>, posted on X, Kennedy vowed to make American food as healthy as it was when he was a child. But teasing causation out of massive epidemiological datasets is difficult. Moreover, distinguishing the effects of additives on chronic disease from those of caloric density and high levels of saturated fat, sugar, and salt in ultra-processed foods will also require longitudinal studies that collect human data over time, Maki and colleagues wrote in a 2024 <a href=\"https:\/\/www.nature.com\/articles\/s41577-024-01049-x\" target=\"_blank\" rel=\"nofollow noopener\">comment article<\/a>. In the meantime, will imposing new restrictions on additives \u2014 including by tightening the GRAS loophole \u2014 generate tangible health benefits?<\/p>\n<p>Kennedy described his March directive to the FDA as one that would promote \u201cradical transparency to make sure all Americans know what is in their food.\u201d Kennedy also said he would direct the FDA and the National Institutes of Health to ramp up post-market assessments of current GRAS chemicals, with an aim towards identifying compounds that are making Americans sick so consumers and regulators can make informed decisions.<\/p>\n<p>Harvard Law School\u2019s Broad Leib said in an email that she is \u201cfully supportive of RFK\u2019s letter directing FDA to see what they can do to address the GRAS pathway.\u201d She also supports any effort to increase post-market surveillance, \u201cbut I think the devil is in the details on whether they are actually going to do such surveillance and enforcement in a way that is impactful.\u201d Achieving these goals will be extremely difficult \u201cgiven the large staffing cuts that have been proposed at FDA and across HHS,\u201d she added.<\/p>\n<p>\u201c[I] think the truth is that we have no idea if tightening up these loopholes will have any effect on chronic disease in America,\u201d Pieter Cohen, an internist at the Cambridge Health Alliance in Massachusetts and prominent commentator on FDA policy, wrote in an email. The strategy might generate transparency for consumers, Cohen noted, allowing them to look for GRAS substances on food labels. Perhaps consumers might avoid ultra-processed diets upon realizing that what they think of as food is \u201cactually just assorted chemicals,\u201d he wrote. But evidence shows consumers in the U.S. are also buying ultra-processed foods in greater amounts. Whether visual, textural, or flavorful, \u201csensory-related industrial additives are the ones that draw you in,\u201d said Elizabeth Dunford, an adjunct assistant professor of nutrition at the University of North Carolina, Chapel Hill. Dunford and her co-authors <a href=\"https:\/\/www.jandonline.org\/article\/S2212-2672(22)01193-5\/abstract\" target=\"_blank\" rel=\"nofollow noopener\">reported<\/a> in 2023 that nearly 60 percent of foods purchased by U.S. households contains chemical additives \u2014 an amount that grew by about 10 percent between 2001 and 2019. At the same time, there was a more than 10 percent decrease in the proportion of products purchased that contained zero additives, she and her team found.<\/p>\n<p>How will consumers react to foods without the familiar look, feel, and tastes they\u2019ve become accustomed to? People who don\u2019t see the bright, pristine colors that artificial dyes provide might \u201cthink the food is adulterated,\u201d Shelke said. Still, the GRAS system could be better monitored to provide assurances of integrity, because when it comes to food safety, she said, \u201ctrust is all we have.\u201d<\/p>\n<div class=\"printfriendly pf-alignleft\"><a href=\"#\" rel=\"nofollow\" onclick=\"window.print(); return false;\" title=\"Printer Friendly, PDF &amp; Email\"><img decoding=\"async\" style=\"border:none;-webkit-box-shadow:none; -moz-box-shadow: none; box-shadow:none; padding:0; margin:0\" src=\"https:\/\/cdn.printfriendly.com\/buttons\/print-button-gray.png\" alt=\"Print Friendly, PDF &amp; Email\"\/><\/a><\/div>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.nakedcapitalism.com\/2025\/04\/what-science-says-about-food-additives.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yves here. This post usefully goes a bit deeper into the regulatory system for food additives. It should come as no surprise that in the<\/p>\n","protected":false},"author":1,"featured_media":93818,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[153,183],"tags":[],"class_list":["post-93817","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-economy","category-spotlight"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/posts\/93817","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/comments?post=93817"}],"version-history":[{"count":0,"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/posts\/93817\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/media\/93818"}],"wp:attachment":[{"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/media?parent=93817"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/categories?post=93817"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neclink.com\/index.php\/wp-json\/wp\/v2\/tags?post=93817"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}